He was 88 and had recently survived a serious bout of double pneumonia.
"Dear brothers and sisters, it is with profound sadness I must announce the death of our Holy Father Francis," Cardinal Kevin Farrell announced on the Vatican's TV channel.
"At 7.35 this morning, the Bishop of Rome, Francis, returned to the house of the Father."
Jorge Mario Bergoglio was elected pope on March 13, 2013, surprising many Church watchers who had seen the Argentine cleric, known for his concern for the poor, as an outsider.
He sought to project simplicity into the grand role and never took possession of the ornate papal apartments in the Apostolic Palace used by his predecessors, saying he preferred to live in a community setting for his "psychological health".
He inherited a Church that was under attack over a child sex abuse scandal and torn by infighting in the Vatican bureaucracy, and was elected with a clear mandate to restore order.
But as his papacy progressed, he faced fierce criticism from conservatives, who accused him of trashing cherished traditions. He also drew the ire of progressives, who felt he should have done much more to reshape the 2,000-year-old Church.
While he struggled with internal dissent, Francis became a global superstar, drawing huge crowds on his many foreign travels as he tirelessly promoted interfaith dialogue and peace, taking the side of the marginalised, such as migrants.
Unique in modern times, there were two men wearing white in the Vatican for much of Francis' rule, with his predecessor Benedict opting to continue to live in the Holy See after his shock resignation in 2013 had opened the way for a new pontiff.
Benedict, a hero of the conservative cause, died in December 2022, finally leaving Francis alone on the papal stage.
Francis appointed nearly 80% of the cardinal electors who will choose the next pope as of February 2025, increasing the possibility that his successor will continue his progressive policies, despite the strong pushback from traditionalists.
The Pope was admitted to the Agostino Gemelli Polyclinic Hospital on February 14, 2025, after suffering from a bout of bronchitis for several days.
Pope Francis’ clinical situation gradually worsened, and his doctors diagnosed bilateral pneumonia on February 18.
After 38 days in the hospital, the late Pope returned to his Vatican residence at the Casa Santa Marta to continue his recovery.
In 1957, in his early 20s, Jorge Mario Bergoglio underwent surgery in his native Argentina to remove a portion of his lung that had been affected by a severe respiratory infection.
As he aged, Pope Francis frequently suffered bouts of respiratory illnesses, even cancelling a planned visit to the United Arab Emirates in November 2023 due to influenza and lung inflammation.
In April 2024, the late Pope Francis approved an updated edition of the liturgical book for papal funeral rites, which will guide the funeral Mass, which has yet to be announced.
The second edition of the Ordo Exsequiarum Romani Pontificis introduces several new elements, including how the Pope’s mortal remains are to be handled after death.
The ascertainment of death takes place in the chapel, rather than in the room where he died, and his body is immediately placed inside the coffin.
According to Archbishop Diego Ravelli, Master of Apostolic Ceremonies, the late Pope Francis had requested that the funeral rites be simplified and focused on expressing the faith of the Church in the Risen Body of Christ.
“The renewed rite,” said Archbishop Ravelli, “seeks to emphasise even more that the funeral of the Roman Pontiff is that of a pastor and disciple of Christ and not of a powerful person of this world.”
Reuters